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KMID : 1234520100050010076
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Korean Journal of Urogenital Tract Infection Inflammation
2010 Volume.5 No. 1 p.76 ~ p.81
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The Effects of Human Acellular Dermal Matrix Injected into Mouse Dermis
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Chang Jin-Suk
Ko Dong-Woo
Lee Hahn-Ey
Oh Yun-Kyu
Son Hwan-Cheol
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Abstract
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Purpose: Soft tissue augmentation using the injectable human acellular dermal matrix is widely used in Opthamology and Otorhinolaryngology. We performed this study to determine the efficacy and safety of injectable human acellular dermal matrix as a bulking agent, which may be applied to vesicoureteral reflux (VUR) or urinary incontinence later on.
Materials and Methods: 0.2ml of normal saline and 0.05, 0.1 and 0.2ml of human acellular dermal matrix were injected into the dermis of the back skin of mouse. At 1, 2, 4, 8 and 12weeks after injection, the volume changes, the histologic changes and the adverse effects were evaluated.
Results: In the mouse receiving injections, over 64% of the volume was maintained at 12weeks. The volume change was proportionate to the injected volume of injectable human acellular dermal matrix (p<0.05). After 8weeks, the volume change was stabilized. No inflammatory reaction was noticed in the mouse.
Conclusions: The injectable human acellular dermal matrix is effective and safe for augmentation of soft connective tissue. Long term follow-up experiment should be required to prove its usefulness in the treatment of urinary incontinence or VUR as a bulking agent.
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KEYWORD
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Injection, Bulking agent, Vesicoureteral reflux, Urinary incontinence
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